D-Ribose-L-Cysteine-rich Supplement Attenuate Doxorubicin-Induced Impaired Spermatogenesis, Testicular Steroidogenesis and Redox Status in Sprague-Dawley Rats

  • Oluwatoyin Ojuolape Medubi, Dr. Department of Physiology, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos.
  • Leke Jacob Medubi, Dr. Department of Anatomy, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos
  • Cecilia Ama Department of Anatomy, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos
  • Nkechi Clara Onwosu Department of Anatomy, Faculty of Basic Medical Sciences, College of Medicine and Health Sciences, Gregory University, Uturu, Abia State.
  • Abraham AA Osinubi, Prof. Department of Anatomy, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos
  • Ramat Olanrewaju Lawal Department of Anatomy, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos
Keywords: Cellgevity™, doxorubicin, antioxidant, testosterone, sperm parameters


Reproductive function is often impaired during chemotherapy and currently there is no universally approved drug/supplement that can effectively protect the testis from cellular assault due to chemotherapeutic agent such as doxorubicin (dox). This study was designed to investigate the efficacy of D-Ribose-L-Cysteine rich supplement, Cellgevity™ (cgvt), in ameliorating some doxorubicin-induced testicular damage in Sprague-Dawley rats. At the end of the study, biochemical assays and sperm epididymal parameters analysis were done. Our results show that simultaneous administration of cgvt and doxorubicin has ameliorative effect on the testis when compared to pre-treatment or post-treatment with cgvt. Significant increase in testosterone, sperm concentration, progressive motility and significant decrease in immotility were observed in the cellgevity treated group. Also, simultaneous administration of cgvt with dox reduced lipid peroxidation and boosted only glutathione level in testicular tissues. Nevertheless, pre-treatment or post-treatment with cgvt did not play a significant role in modulating sperm parameters, hormones and tissue oxidative stress level. This result reveals that cellgevity has testiculo-protective effect against doxorubicin administration.


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